Calcium dependence of damage to mouse motor nerve terminals following oxygen/glucose deprivation
نویسندگان
چکیده
منابع مشابه
Calcium-dependent depolarizations originating in lizard motor nerve terminals.
Action potentials and afterpotentials were recorded via a microelectrode inserted into motor axons innervating the lizard ceratomandibularis muscle. Intra-axonal injection of Lucifer yellow dye indicated that these axons innervate multiple (at least 6-25) motor terminals. In 10 mM tetraethylammonium (TEA), the action potential was followed by a sequence of afterpotentials, whose amplitude and d...
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We have used fura-2 fluorescence to study the effects of repetitive stimulation producing posttetanic potentiation (PTP) at crayfish neuromuscular junctions on presynaptic calcium concentration. Fura-2 was injected into the preterminal axon of the excitor motor neuron to the claw opener muscle of a walking leg. Pictures of presynaptic terminals on the muscle surface were obtained with a charge-...
متن کاملalpha-Latrotoxin releases calcium in frog motor nerve terminals.
alpha-Latrotoxin (alpha-LTX) is a neurotoxin that accelerates spontaneous exocytosis independently of extracellular Ca(2+). Although alpha-LTX increases spontaneous transmitter release at synapses, the mechanism is unknown. We tested the hypothesis that alpha-LTX causes transmitter release by mobilizing intracellular Ca(2+) in frog motor nerve terminals. Transmitter release was measured electro...
متن کاملAbsence of [125I] alpha-bungarotoxin binding to motor nerve terminals of frog, lizard and mouse muscle.
The existence of nicotinic acetylcholine receptors (AChRs) on the motor nerve terminals of vertebrates has long been controversial. We have re-examined this issue by electron microscope autoradiography with [125I] alpha-bungarotoxin, following separation of nerve terminals from muscle fibers by collagenase and protease treatment. We found no label over nerve terminal membranes other than that d...
متن کاملLocalization of Calcium in Presynaptic Nerve Terminals
Ultrastructural techniques and electron probe microanalysis were used to determine whether or not the smooth endoplasmic reticulum (SER) within presynaptic nerve terminals is a Ca-sequestering site . The three-dimensional structure of the SER was determined from serial sections of synaptosomes. The SER consists of flattened cisterns that may branch and are frequently juxtaposed to mitochondria ...
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ژورنال
عنوان ژورنال: Experimental Neurology
سال: 2012
ISSN: 0014-4886
DOI: 10.1016/j.expneurol.2011.12.020